Sheikh was born into a Muslim family in Jammu and Kashmir. He studied science 10+2 at Hari Singh Higher Secondary School, Jammu.
Sheikh started his career as a photographer and model but later become an actor. He started his acting career with Kya Mast Hai Life on Disney Channel India and Jhansi Ki Rani on Zee TV.
He then acted in Best Of Luck Nikki on Disney Channel India as a recur character.
Shaheer Sheikh is currently essaying the lead Role of a young business tycoon Dev Dixit in Sony Entertainment Television's popular show Kuch Rang Pyar Ke Aise Bhi.
Shaheer is paired opposite a newcomer Erica Fernandes in the show. Shaheer is popular for his characters in shows like Navya and Mahabharat both on Star Plus.
In 2011, he won the Taaza male award and the Great! face of the year award at the BIG Television Awards for Navya.